Osteomalacia involves softening of the bones caused by a deficiency of vitamin D or problems with the metabolism of this vitamin.

Causes, incidence, and risk factors

There are numerous causes of osteomalacia. In children, the condition is called rickets and is usually caused by a deficiency of vitamin D . Conditions that may lead to osteomalacia include inadequate dietary intake of vitamin D, inadequate exposure to sunlight (ultraviolet radiation), which produces vitamin D in the body and malabsorption of vitamin D by the intestines. Other conditions that can cause osteomalacia include hereditary or acquired disorders of vitamin D metabolism ; kidney failure and acidosis ; phosphate depletion associated with low dietary intake of phosphates; kidney disease or cancer (rare), and side effects of medications used to treat seizures . Risk factors are related to the causes. In the elderly, there is an increased risk amongst those who tend to remain indoors and who avoid milk because of lactose intolerance . Use of very strong sunscreen, limited exposure of the body to sunlight, short days of sunlight, and smog are factors that decrease formation of vitamin D within the body.

Signs and tests

A

bone biopsy shows osteomalacia.

Serum

vitamin D level may be low.

Serum calcium

levels vary with the cause of the disorder.

Serum phosphate

levels vary with the cause of the disorder.

A

bone X-ray may show features of osteomalacia.

a bone mineral density scan (DEXA) may show reduced bone mineral density

Other tests may be done to determine renal problems or other underlying disorders. They include:

PTH

Calcium (ionized)

ALP (alkaline phosphatase) isoenzyme

Treatment

Oral supplements of

vitamin D , calcium and phosphorus may be given depending on the underlying cause of the disorder. Larger doses of vitamin D and calcium may be needed for people with intestinal malabsorption . Monitoring of blood levels of phosphorus and calcium may be indicated for people with certain underlying conditions.

Expectations (prognosis)

Improvement in the condition of the bones, evidenced by bone X-rays , can be seen within a few weeks in some people with vitamin deficiency disorders. Complete healing with treatment takes place in 6 months.

Complications

Recurrence of symptoms is a possible complication.

Calling your health care provider

Call for an appointment with your health care provider if you have symptoms of osteomalacia, or if you think that you may be at risk for this disorder.

Prevention

An adequate dietary intake of dairy products that are fortified with vitamin D and exposure of the body to sunlight can prevent osteomalacia caused by vitamin D deficiency in adults.