A sexually transmitted or congenital infection caused by the bacterium Treponema pallidum . See also documents on Syphilis; primary , Syphilis; secondary , and Syphilis; tertiary .

Alternative Names

Lues

Causes, incidence, and risk factors

Syphilis is an infectious disease caused by the spirochete Treponema pallidum , which penetrates broken skin or mucous membranes. Transmission occurs most frequently by sexual contact. Syphilis can also be transmitted to the fetus during any stage in pregnancy. Syphilis is widespread in the United States and primarily involves sexually active adults between 20-29 years of age. Syphilis has several stages. In the primary stage, painless sores, called chancres , appear approximately 2-3 weeks after initial exposure. Some individuals with primary syphilis may not notice chancres nor have symptoms associated with them, in particular if the chancres are located in the rectum or cervix. In about 4 to 6 weeks chancres will usually disappear. Approximately one-third of untreated individuals will progress to the second stage: secondary syphilis . This usually occurs at about 2 to 8 weeks after the appearance of the original chancre in some cases the chancre may still be present. Secondary syphilis is the stage where the bacteria have spread in the bloodstream and have reached their highest numbers. The most common symptoms include: skin rash which can be varied in appearance, yet frequently involves the palms and soles, in addition to lesions in the mouth, vagina, penis (mucous patches), swollen lymph nodes, and fever. This stage is the most contagious stage of syphilis. It usually resolves within weeks to a year. A latent phase follows, which may last for years and is characterized by the absence of symptoms. The final stage of syphilis is called tertiary syphilis ( syphilis; tertiary) and is characterized by brain or central nervous system involvement (neurosyphilis), cardiovascular involvement with inflammation of the aorta (aortitis or aneurysms), and gummatous syphilis (destructive lesions of the skin and bones).

Signs and tests

The proper diagnostic tests for syphilis depend on the stage of the disease and may include: dark field examination of primary lesion (in primary syphilis), and blood tests such as VDRL or RPR and FTA-ABS. In the case of neurosyphilis, a spinal tap is required to make the diagnosis and may be sent for VDRL and/or FTA-ABS.

Treatment

The mainstay of therapy for syphilis is proper antibiotic treatment. The antibiotic of choice is penicillin, yet doxycycline may be used as an alternative in individuals with a penicillin allergy. Penicillin is given either intramuscularly or intravenously depending on the stage of syphilis. Syphilis is a reportable infection -- that is, it must be reported to public health authorities for assistance in identifying and treating potentially infected sexual partners. After appropriate antibiotic treatment is given for syphilis, follow up blood tests ( RPR ) are usually performed to assess the adequacy of treatment.

Expectations (prognosis)

Prompt treatment and monitoring for response to treatment for syphilis can cure the disease. Once late complications develop (tertiary syphilis), long-term health problems are likely despite therapy.

Complications

The complications of syphilis are related to the development of the syndromes associated with tertiary syphilis:

Calling your health care provider

Notify your health care provider if you develop signs or symptoms of syphilis -- while there are several conditions which may have similar symptoms, you will need to undergo a careful medical evaluation.

Prevention

Safer sexual practices and consistent condom use are important measures in the prevention of syphilis. In addition, early diagnosis and treatment is needed to prevent ongoing transmission of this disease, as is screening during any evaluation for a sexually transmitted disease. Screening of all pregnant women for syphilis is another measure to decrease the risk that the disease will be passed on to the fetus.